normally when we are using sqlite in c# / for vb code ‘Mixed mode assembly is built against version ‘v2.0.50727’ of the runtime and cannot be loaded in the 4.0 runtime – Researched solutions not working ‘ or ‘Error: mixed mode assembly is built against version v2.0.50727 of the runtime and cannot be loaded in the 4.0 runtime without additional configuration information’ concurs
open your app.config in your SolutionExplorer
replace your app.config with below configuration code
<?xml version="1.0" encoding="utf-8"?>
<configuration>
<startup useLegacyV2RuntimeActivationPolicy="true">
<supportedRuntime version="v4.0"/> sku=".NETFramework,Version=v4.0"/>
</startup></configuration>